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December 9, 1905

MINIMAL ALBUMIN REQUIREMENTS IN HEALTH AND DISEASE.

JAMA. 1905;XLV(24):1775-1776. doi:10.1001/jama.1905.52510240005001a
Abstract

In 1891 I published1 a series of experiments on the subject of the quantity of albumin necessary to keep a human individual in a normal nitrogen equilibrium.

At that time the quantity of albumin considered necessary for an adult in 24 hours was 118 grams, these figures resting on experiments made by Voit and his pupils.

I experimented on myself for a period of thirty days. The food, which was the same in quantity and quality for every twenty-four hours of the thirty days of experimentation, consisted of meat, rice, potatoes, bread, corn-starch, eggs, milk, sugar and butter, and contained 67.80 grams of albumin. The average quantity of nitrogen excreted in the form of urea by the urine, and estimated by the Kjeldahl method, amounted to 8.23 grams for every twenty-four hours, which, computed as albumin, amounts to 51.4 grams. This would leave 16.40 grams of albumin, or 2.62

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