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December 9, 1905


JAMA. 1905;XLV(24):1804. doi:10.1001/jama.1905.02510240036006

The hyperplastic degenerative process designated arteriosclerosis may be looked on as the anatomic expression of old age, mature or premature. Secondary to it the nutrition of the tissues generally suffers with atrophy of parenchymatous structures and increased production of interstitial tissue. These alterations naturally are attended with varied functional disturbances, taking for example, in the sphere of the nervous system, the form of impaired mental, motor and sensory activity. Changes of a related character may be due, likewise, to atrophy of nerve cells, perhaps from toxic influences, although here, too, the vessels are not likely altogether to escape. A good deal of attention has been given to this subject in recent years, and an interesting exposition of the relations between sclerosis of the cerebral vessels and various forms of mental disease is given by Dr. Albert M. Barrett,1 supplemented by a detailed account of illustrative cases, with description of