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Article
December 23, 1905

THE PHARMACOLOGY OF DIETHYLOXYACETYL UREA.

Author Affiliations

DETROIT, MICH.

JAMA. 1905;XLV(26):1917-1920. doi:10.1001/jama.1905.52510260003001a
Abstract

Some weeks ago my attention was called to a new group of chemical bodies belonging to the methane series. According to A. H. C. Heitmann and Erik Clemmensen, the discoverers, they are condensation products of urea and the various oxyacetic acids. A consideration of the chemical structure of these compounds led to the belief that all would possess considerable hypnotic power, but the ethyl compound was thought to be the more promising for therapeutic purposes. The originators accordingly prepared and placed at my disposal sufficient quantities of the ethyl derivative in its pure state, and a little later its sodium salt, to undertake a series of animal experiments to demonstrate its pharmacologic properties.

Perhaps the most desirable chemical name that can be given to the compound, as indicating its structure, is the one mentioned in the title of the paper, diethyloxyacetyl urea. The chemical formula is given by Clemmensen and

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