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May 16, 1914

THE ETIOLOGY OF TYPHUS FEVER (AND OF BRILL'S DISEASE). PRELIMINARY COMMUNICATION: HARRY PLOTZ, M.D. NEW YORK

JAMA. 1914;LXII(20):1556. doi:10.1001/jama.1914.02560450038015

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Abstract

Basing my opinion on some theoretical considerations and on previous investigations, I considered it advisable to search for an anaerobic organism as the etiologic factor in the acute infectious disease of unknown origin which Brill differentiated from typhoid fever. By the use of anaerobic methods in six cases of Brill's disease, I obtained the same organism in five; the case in which the organism was not obtained was investigated only after the crisis. Inasmuch as studies made during the past few years have shown that Brill's disease is probably a mild form of typhus fever, I decided to apply the same methods to the study of the latter. Through the kindness of Dr. Joseph O'Connell, health officer of the port of New York, to whom I am deeply indebted, I was enabled to study six cases of typhus fever at the height of the disease, and from all of these

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