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September 25, 1897

The Liver of Dyspeptics; and particularly the Cirrhosis Produced by Auto-Intoxication of Gastro-Intestinal Origin.

JAMA. 1897;XXIX(13):661. doi:10.1001/jama.1897.02440390051025

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In this work Dr. Boix seeks to establish the fact that in addition to alcohol as a cause of hepatic cirrhosis, and independent of some other hitherto recognized causes, there is auto-intoxication present, and this auto-intoxication is of gastro-intestinal origin. The author has, we think, demonstrated that there is a peculiar form of hypertrophic cirrhosis which is caused by the passage through the liver of toxic substances produced in a diseased alimentary canal, and he uses the term "dyspeptic liver" just as the term "alcoholic liver" is used to designate the effect of another form of cirrhosis.

The first part includes three chapters, one treating of auto-intoxication of gastro-intestinal origin; the second enumerating products of fermentation capable of exercising a pathogenic action; third, conditions which favor abnormal fermentations and the production of these poisons. In the second part, after some preliminary considerations in regard to the antitoxic role of the

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