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December 30, 1905


Author Affiliations

Associate Professor of Bacteriology and Pathology, University of Kansas. LAWRENCE, KAN.

JAMA. 1905;XLV(27):2013-2014. doi:10.1001/jama.1905.52510270019002f

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Some seven or eight years ago, in late summer, I found in this vicinity several fruits of the common papaw which had fallen to the ground and ripened prematurely. The fruit was ripe enough to be palatable, and I ate a small portion, perhaps equivalent to one fruit. About six hours later I experienced an urticaria, beginning with itching and burning in the hair at the back of the head and soon extending over a considerable part of the body. Accompanying symptoms were nausea, throbbing at the head and disturbance of the bowels. The urticaria would at times diminish suddenly; then the nausea would increase, to be relieved a few moments later with the reappearance of the "hives." The symptoms lasted several hours, but they had almost wholly disappeared by the next morning and the skin had resumed its normal condition. A friend ate some of the fruit at the

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