Following is a report of twelve cases of human brain infection with the pneumococcus, together with the results of inoculation of the pneumococcus in the brains of guinea-pigs. Both the human and the experimental material have been used to establish the order and time relations of the acute inflammatory changes. The work is on the lines of our study of encephalitis due to the Staphylococcus pyogenes aureus,1 but was particularly suggested by the case of pneumococcus brain infection (here abstracted as Case 1) reported by Bullard and Sims2 from this laboratory in 1904.
Profs. W. T. Councilman and F. B. Mallory have looked over the work. On the bacteriologic side we have been much aided by Drs. C. W. Duval and P. A. Lewis, of the hospital staff. We wish to thank Drs. J. H. McCollom, A. L. Mason, G. B. Shattuck, F. H. Williams, C. F. Withington,
SOUTHARD EE, KEENE CW. A STUDY OF BRAIN INFECTIONS WITH THE PNEUMOCOCCUS. JAMA. 1906;XLVI(1):13–21. doi:10.1001/jama.1906.62510280013001c
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