It is customary to include in any summary of the causes of cancer the blanket term "chronic irritation." Prominent under this heading are the inflammations peculiar to the influence of tar, paraffin, anilin, tobacco and soot; lupus vulgaris (a small proportion) and other types of cutaneous tuberculosis; ulcerating syphilis, rarely; irritated warts and pigmented moles; cicatrices, especially from burns or chronic leg-ulcer; circumscribed keratoses — cutaneous horns — callosities, palmar and plantar arsenical lesions; leukoplakia buccalis and lesions in the neighborhood of jagged teeth, senile keratomas.1 Hyde2 mentions exposure to sunlight, while the almost mathematical certainty with which cancer may be induced by the Roentgen ray has become a matter of common knowledge.
The dermatitis resulting from paraffin irritation was first discussed at length by Volkmann,3 who distinguishes an acute and a chronic stage. The acute stage expresses itself in various eruptions that are at times acneform
DAVIS BF. PARAFFIN CANCERCCAL AND PETROLEUM PRODUCTS AS CAUSES OF CHRONIC IRRITATION AND CANCER. JAMA. 1914;LXII(22):1716–1720. doi:10.1001/jama.1914.02560470016006
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