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Article
January 6, 1906

AN ANALYTIC STUDY OF UREMIA.WITH SOME GENERAL CONCLUSIONS IN REGARD TO ITS CAUSES AND TREATMENT.

JAMA. 1906;XLVI(1):34-37. doi:10.1001/jama.1906.62510280034001i
Abstract

CRITIQUE OF CURRENT UREMIA THEORIES.  If the current belief that uremia is due to renal inadequacy and the retention in the blood and tissues of excrementitious urinary bodies were correct, then (1) complete anuria should always produce uremia, and (2) the blood of uremic patients should always show an increase and the urine a corresponding decrease of urinary substances.

Anuria Without Uremia.  —Many cases of complete anuria, due to various causes, are, however, recorded, in some instances persisting for several weeks, in which none of the characteristic phenomena of uremia developed. Most of these patients for days complained of nothing more than a feeling of extreme lassitude, death resulting suddenly from heart failure without preceding coma or amaurosis, and without eclamptic spasms or typic changes of the blood pressure. On the other hand, uremia not infrequently occurs when the flow of urine is abundant and the excretion of urinary solids

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