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Within the past five weeks I have had an opportunity of experimenting with tetanus antitoxin in the treatment of two cases of trismus nascentium. This disease of infancy has been almost uniformly fatal and, notwithstanding the fact that all kinds of treatment have been used, has thus far resisted every measure.
On learning of the successful treatment of tetanus in the adult by the serum treatment, I determined to try the same remedy for the infantile disease. By reason of the extreme youth of the patient one has no guide as to the quantity of the serum to be used. As will be seen in the first case, knowing that the child would die under the ordinary plan of treatment, a large dose was used in the beginning, considering the weight of the child as compared with that of the adult, in which a full bottle is usually administered.
FRIEDMAN J. TWO CASES OF TRISMUS NASCENTIUM SUCCESSFULLY TREATED BY TETANUS ANTITOXIN. JAMA. 1897;XXIX(15):727. doi:10.1001/jama.1897.02440410015002d
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