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Article
December 5, 1896

DO GRAPE SEEDS CAUSE APPENDICITIS?

JAMA. 1896;XXVII(23):1196-1197. doi:10.1001/jama.1896.02431010024002j

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Abstract

The laity of Chicago have become infected with the idea that grapes are a dangerous fruit. They have received from some of our best physicians an opinion that grape seeds cause many, or perhaps nearly all of the cases of appendicitis occuring among us, and the occasional discovery of a seed in or near a perforated appendix adds to the alarm.

Nearly all the grapes consumed in this city are eaten in the months of August, September, October and November. If they cause any large number of cases of appendicitis, we would expect that disease to be most frequent during the grape eating season, or at least within a reasonable period after its close.

To settle this question, I have obtained statistics of the disease in Chicago for every month during the last fourteen years. My friend, Mr. Tracy H. Clark, a medical student, has been kind enough to examine

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