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December 5, 1896


Author Affiliations


JAMA. 1896;XXVII(23):1198. doi:10.1001/jama.1896.02431010026002k

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Veratrum viride slows the heart's action and makes it more feeble. It was first used by Magendie and Andral in physiologic experiments in 1821. Meisner first discovered it in the seeds of veratrum sabadilla in 1818. Bardsley first used it in rheumatism and dropsy in 1826. The curative effect of veratrum viride lies in its influence on the heart to retard its action in acute inflammatory diseases wherein the pulsation is very much accelerated. I have been able to produce the physiologic effects of the drug in cases of inflammatory diseases with a dose of Norwood's tincture not larger than three drops every three hours. By this dose I have been enabled to reduce the pulse beat twenty or thirty in a minute, especially when the high pulse rate has been caused by inflammation. In inflammatory rheumatism I have had good results with this drug by keeping the pulse at

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