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June 6, 1914

Cholesterinized Antigens

JAMA. 1914;LXII(23):1829. doi:10.1001/jama.1914.02560480063032

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To the Editor:  —In The Journal, May 9, 1914, p. 1458, there is an article by Dr. Loyd Thompson on the use of cholesterinized antigens in the Wassermann reaction, in which he strongly disagrees with the findings reported by us in a previous article (The Journal, Jan. 31, 1914, p. 363), asserting that his series of 356 tests is a larger series than ours from which to draw conclusions. As a matter of fact, the number of cases in which Thompson employed the cholesterinized antigen controlled by the syphilitic liver antigen was only 50, as compared with 133 cases in our series. The results given by Thompson, based on examination of 306 cases in which the cholesterinized extract alone was used, obviously furnish no basis of comparison between the merits of the two antigens, and we feel that we should have obtained practically the same results with syphilitic liver antigen.

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