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January 13, 1906


Author Affiliations


From the Hygienic Laboratory, University of Michigan.

JAMA. 1906;XLVI(2):116. doi:10.1001/jama.1906.62510290036001i

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PRELIMINARY NOTE.  The spirochete studied was obtained through the kindness of Dr. Norris of Bellevue Hospital, New York, who secured it from a case of relapsing fever by inoculating the blood into monkeys and white rats. The organism has been kept alive by successive passage through white rats for over two months. As a result of intraperitoneal injection the parasites appear in the blood in thirty-six to forty-eight hours after inoculation, disappear within the next twenty-four hours and do not reappear. The rats are then immune to subsequent inoculation. The disappearance of the spirochetes was shown to be due to the formation of anti-bodies. Spirochetal blood, when kept in vitro, retains its virulence for more than fifteen days.The blood of rats which have been given repeated injections of spirochetal blood exerts a most marked preventive and curative action. When injections of such blood are made, before inoculation with spirochetes,

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