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There is probably no class of diseases that is so little understood, and for which it is so difficult to obtain any conception of the etiology, as certain bone diseases. In the bone diseases in which the etiology is known, as in those of an infectious character, the processes going on are not at all understood. This is true in part because so little is known of the chemistry of bone metabolism. Of all the various chemical processes in the body, that which gives rise to bone formation appears to be the simplest because of the inorganic constituents involved whose chemistry is so thoroughly known. While the resulting products are known, however, as is true in many other tissue reactions, the manner in which these substances are brought there and the processes occurring before the final products appear are mostly in the realm of speculation. Bone absorption also is a
CHEMISTRY OF OSTEOMALACIA. JAMA. 1906;XLVI(3):196–197. doi:10.1001/jama.1906.02510300030005
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