—In this serious disease we have to consider a condition very different from those previously described, in that they are due to an increased functional activity of the gland. The view that a hyperthyreosis is the underlying cause, is based on several facts, as follows: The symptoms are almost identical with those observed after administration of overdoses of thyroid extract, viz., tachycardia, tremor, headache, prostration and sweating; and a certain degree of exophthalmos has sometimes been observed during thyroid treatment. Exophthalmic goiter has been known to follow an overdose of the extract. The structure of the gland in this disease is almost exactly reproduced in glands stimulated to the highest degree of activity. Halsted, by removing large portions of the thyroid from dogs, has produced a compensatory hypertrophy in the remaining stumps, and he describes the changes as consisting of a branching of the acini with foldings in
WELLS HG. THE PHYSIOLOGY AND THERAPEUTICS OF THE THYROID GLAND AND ITS CONGENERS. JAMA. 1897;XXIX(20):1007–1011. doi:10.1001/jama.1897.02440460027002h
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