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Of the many unsolved problems in pathology none perhaps possesses a greater interest to both theorist and practitioner than does the origin of diabetes mellitus. Its etiology is even yet shrouded in mystery, notwithstanding the enormous amount of study that has been devoted to it, and the situation may be summarized in the statement that of no other pathologic condition is there so much known, and yet so little. Many and various have been the theories advanced from time to time, each having a few facts apparently supporting it, but as they conflicted with each other in important particulars, one after another they were abandoned, for the advancement in physiologic chemistry made it possible more and more to explain the different and complex processes by means of which the several classes of foods passed through stage after stage of preparation and elaboration until they were fit to become incorporated into
RAMUS C. DIABETES AND OBSCURE PHYSIOLOGY. JAMA. 1904;XLII(6):364–370. doi:10.1001/jama.1904.92490510015002b
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