Billroth and Neuber1 were the first to employ osmic acid for neuralgia. They used repeated injections by puncture through the skin without exposure of the nerve; as many as twenty injections were given in some cases. Eulenburg,2 employing a similar method, had good results in only 3 out of 13 cases, which included neuralgias of the brachial, sciatic and trigeminal nerves. Schapiro,1 who used a 1 per cent. solution of osmic acid in glycerin and water, records 5 successes out of 8 cases at periods of two to six months after injection. Jacoby3 claims 8 cases of cure out of 18 sciaticas, and warns us that it is "dangerous to implicate a motor nerve." Cohen4 of Philadelphia used repeated injections (without exposure) into the sciatic nerve, using as much as 30 minims of a 1 per cent. solution. Ellis3 records the occurrence of some
EASTMAN JR. THE EFFECTS OF OSMIC ACID INJECTIONS. JAMA. 1906;XLVI(8):556–560. doi:10.1001/jama.1906.62510350006001b
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