The influence of sodium chlorid on the dropsies attending various forms of nephritis was brought to the attention of the medical world in a paper by F. Widal and A. Javal,1 which has been noticed2 in these columns. Since then the study of the fate of sodium chlorid in the body and the influence of that salt on dropsies and edemas has been diligently pursued by the French clinicians. According to the investigations of R. Marie,3 it appears that when sodium chlorid is not eliminated it does not remain in the blood, but passes into the interstitial circulation, where it reaches a fixed percentage, usually about six grams to the thousand. When the retention is increased, the strength of the plasma does not change, but the tissues become more hydrated, and when the retention becomes very marked, the interstitial fluid becomes greatly increased and edema results. All
THE INFLUENCE OF SODIUM CHLORID AND DECHLORIDATION ON CARDIAC AND OTHER DROPSIES. JAMA. 1904;XLII(6):377–378. doi:https://doi.org/10.1001/jama.1904.02490510031004
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