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December 11, 1897


JAMA. 1897;XXIX(24):1224-1225. doi:10.1001/jama.1897.02440500038007

The leucocytes in acute inflammation not only act as phagocytes and as carriers of bactericidal substances that are secreted or liberated on disintegration, but the presence of leucocytes within formative cells is usually interpreted as signifying an additional supply of food for the rapidly growing cells. Klebs1 and Ranvier,2 in particular, lay stress upon this rôle of the leucocytes. In addition to its bactericidal, diluent and irrigant action the exudate also furnishes the proliferating cells with abundant nourishment. The precipitation of fibrin in inflammatory exudates can also be regarded as beneficial in so far as the fibrinous adhesions often seem to circumscribe the action of the bacteria. The inflammatory proliferation of the fixed tissue cells may be regarded as not only regenerative but as an effort to build a protective wall between the bacteria and the healthy tissue. The experiments of Afanasieff show that healthy granulation tissue is

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