The object of this paper is to state the sequence of the changes which occur in the bones in infectious osteomyelitis; to emphasize the difference in the pathologic conditions which exist during the acute, subacute and chronic stages of the disease; and especially to suggest certain operations which are indicated by the pathologic conditions that exist during the different stages, and which generally are not appreciated. These operations, properly carried out, offer a very certain cure for conditions which, if allowed to persist, cause recurrent attacks of local infection or produce chronic and frequently incurable destruction of bone with permanent disability.The statements made here are based almost entirely on personal work carried on for the past eight years. The work has included examination of pathologic material obtained from operations or necropsies on cases occurring at the Boston City Hospital and the Children's Hospital, experimental work at Harvard Medical
NICHOLS EH. ACUTE, SUBACUTE AND CHRONIC INFECTIOUS OSTEOMYELITIS;ITS PATHOLOGY AND TREATMENT. JAMA. 1904;XLII(7):439–466. doi:10.1001/jama.1904.02490520029002
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