It has long been known that sarcomatous changes may occur in myomata. In 18601 Virchow gave a very clear account of the gross and histologic pictures in such cases. In 18722 Chrobak drew attention to this class of cases, and in 18873 Ritter gave a full survey of the literature up to that date. The question was fully discussed by Williams,4 as well as by Schreher,5 in 1894; and in 1895 by L. Pick.6 The article of Gessner,7 published in 1899, is the most exhaustive that we possess, and will well reward a thorough study. Among the more recent and lucid articles is that of Wier,8 published in 1901, and that of Jacobi and Wollstein,9 which appeared in 1902.
But it was the excellent paper by Charles P. Noble, that first thoroughly aroused gynecologists to an appreciation of the possible danger
CULLEN TS. IMMEDIATE EXAMINATION OF UTERINE MUCOSA AND MYOMATOUS NODULES AFTER HYSTEROMYOMECTOMY TO EXCLUDE MALIGNANT DISEASE. JAMA. 1906;XLVI(10):695–698. doi:10.1001/jama.1906.62510370001001
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