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February 20, 1904


JAMA. 1904;XLII(8):514-521. doi:10.1001/jama.1904.92490530016001c

GENERAL STATEMENT.  The eyes become involved as a result of the general systemic conditions arising in Bright's disease. These systemic conditions, briefly considered, are the result of faulty kidney excretion, leading to the retention of urea or other excrementitious substances in the blood. These retained products are either poisonous in themselves or secondarily lead to the formation of toxins, thus producing inflammatory and degenerative changes in the vessel walls and the tissues of the body; or they may interfere with the proper conversion of the elements of food into those favorable for assimilation by the cells of the body, thus producing anemia and hydremia. To this abnormal condition of the blood is attributed the general arteriofibrosis, which finds its expression in hypertrophy of the heart and general increased arterial tension, leading to exudation and hemorrhage or total occlusion of the arterioles, with subsequent death of the parts cut off.In

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