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March 17, 1906


Author Affiliations


From the Hearst Laboratory of Pathology, University of California.

JAMA. 1906;XLVI(11):790-791. doi:10.1001/jama.1906.62510380028001f

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The interest of the surgical section of the medical profession is just now deeply concerned with the question of acetonuria. This interest has been awakened by observations of the frequent occurrence of the urinary acetone-complex following anesthesia and associated with a toxicosis that has been fatal in a number of instances. That acetone occurs frequently following anesthesia has been long known, and that it frequently occurs following the ingestion of many narcotics is equally well known. That the toxicosis is the result of the acetone-complex, that it is, in other words, an acid intoxication, is not demonstrated. On the contrary, it is much more probable that the toxicosis and the acetonecomplex are fellow results of a widespread autolytic degeneration, of a ferment intoxication that has been in some unknown way inaugurated by the anesthetic or narcotic. It is known that many poisons act, in large part, by the inauguration of

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