One of the many debatable questions in tuberculosis is that of mixed infection. Some observers account for nearly all elevations of temperature which pass beyond a very moderate limit as being due to a mixed infection. Others, on the contrary, question whether the advent of other bacteria into the field of tuberculosis has anything to do with the production of the fever, even that of the hectic type.
Many bacteria besides the tubercle bacillus are found in tuberculous sputum. The various pus organisms, especially the streptococci, are commonly present. That these various organisms are found in the sputum is not sufficient ground for associating them with the tuberculous process, for they may have come from the mouth, throat or other portions of the respiratory tract. To obviate this possibility of error Pfeiffer1 suggested that the particles of sputum for examination be taken from the center of the mass of
POTTENGER FM, BROWNING CC. A CLINICAL STUDY OF MIXED INFECTION IN TUBERCULOSIS.PRELIMINARY REPORT. JAMA. 1906;XLVI(12):863–866. doi:10.1001/jama.1906.62510390021001e
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