My attention was first called to this condition some six years ago, when a solution composed of Goulard's extract and tincture of opium, of each 1.5 oz. to a quart of water, was ordered to be applied warm to a knee which had been injured by a fall. In twenty-four hours a diffuse erythema with intense itching and burning developed over the area to which the solution was applied. The patient complained more of this than of the injury. The second instance was as follows:
The patient was a corpulent woman who was suffering from a very much inflamed leg of varicose origin, which threatened to break down and form an ulcer. The above solution was applied in the same manner. Again in twenty-four hours, when I next saw her, there was a very pronounced erythema, corresponding to the part to which the solution had been applied. The patient complained
BLACKBURN AE. IDIOSYNCRASY TO LEAD-WATER AND LAUDANUM. JAMA. 1906;XLVI(13):954–955. doi:10.1001/jama.1906.62510400032003
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