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April 7, 1906


Author Affiliations

Professor of the Principles and Practice of Medicine, Johns Hopkins University; Physician-in-Chief to the Johns Hopkins Hospital. BALTIMORE.

JAMA. 1906;XLVI(14):1006-1011. doi:10.1001/jama.1906.02510410008002

(Concluded from Page 935.)

The next questions to be decided are, (1) Do the minute fibers ending in the terminal buttons form anastomoses with one another? and (2) Do neurofibrils pass from the terminal buttons into the adjacent cell body or dendrite to form connections with the neurofibrils lying in the protoplasm there? I am unable to find them in the preparations I have been studying, nor can Ramón y Cajal, von Lenhossék, Retzius, van Gehuchten or Mahaim in theirs. Held12 thinks that he sees such communications, and Max Wolff is inclined to a similar view. Further study is needed to decide this point.

Ramón y Cajal is so convinced of the separateness of the terminal buttons from the adjacent nerve-cell protoplasm that he unhesitatingly assures us that not only is the neuron conception valid, but even the contact doctrine is better supported now than ever before, and Sherrington