It is rather curious that in the fight against infectious diseases in the human being vaccination in the true sense has been used but little, aside from its use as a preventive of smallpox. In the sense meant by Jenner and Pasteur, vaccination refers to inoculation with a living organism of attenuated virulence, and it seems desirable in the interests of lucidity that the term should be so restricted and should not be employed to designate forms of protective inoculation in which killed organisms or their extracts are employed.
We have frequently pointed out in these columns the difference between diseases due to bacteria which excrete their toxins and those due to bacteria in which the toxins are intimately associated with the body of the bacterial cell. Most human infectious diseases are caused by bacteria of the second group, and, as it is in animal diseases of this group that
VACCINATION AGAINST PLAGUE. JAMA. 1906;XLVI(15):1114–1115. doi:10.1001/jama.1906.02510420044009
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