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September 7, 1895


JAMA. 1895;XXV(10):419-420. doi:10.1001/jama.1895.02430360033003

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The pathology of Basedow—Graves' disease, or exophthalmic goitre is one of the questions that is just at present to the fore in neurologic medicine, and has been the subject of one or two rather noteworthy papers in recent periodical literature. Formerly the generally prevalent notion in regard to it, as far as there could be said to be any definite theory, was that it was a disorder of the sympathetic system and the vagus, probably connected with some lesion, functional or organic, of the centers in the medulla. This view, held in varying degrees of indefiniteness may be said to have predominated up to a comparatively recent date. Within a few years, however, the thyroidean theory of the affection has come into vogue and may be said to be perhaps the one that is most popular at the present time; it is that the disease is the result of an

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