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October 12, 1895


Author Affiliations


JAMA. 1895;XXV(15):621-622. doi:10.1001/jama.1895.02430410021001i

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I wish to bring to your attention the results of some studies I have recently made upon bromoform; its chemistry, pharmacology, and therapeutic action in certain diseases.

Bromoform is a colorless liquid of sp. gr. 2.83 at 0 degrees C., and is represented by the symbol C H Br. 3. It is produced by the action of bromin upon alcohol in the presence of an alkali. In practice, milk of lime is saturated with bromin, alcohol is added, and the mixture distilled. The resulting liquid is colorless, sweet to the taste, and gives the sensation of burning. Its physiology may be summed up in saying that it is an agreeable anesthetic, without danger, merely lowering blood pressure; a narcotic when used hypodermically; and, finally, is an antipyretic. The excitability of the psychomotor centers and the general reflexes are entirely abolished when anesthesia is complete. The urine contains bromin some hours

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