To return to our subject of focal immunity. This, as contrasted with a general resistance, is probably the chief stumbling block to successful artificial immunization. To bring about the latter the whole body has to be exposed to the immunizing (and toxic) substances, as there is no other way of reaching certain avenues or portals of entry which are exposed to invasion. We might, for instance, cause the inhalation of an impalpable dust or spray of ground tubercle bacilli to increase the resistance of the lungs in the healthy and the diseased, but then the greatest care would have to be exercised not to give an overdose to an affected lung; otherwise a very severe or even fatal congestion due to the local tuberculin reaction might result.
This problem of local immunity and its relation to a general immunity has occupied my attention for a number of years. Beginning in
SMITH T. THE PARASITISM OF THE TUBERCLE BACILLUS AND ITS BEARING ON INFECTION AND IMMUNITY. JAMA. 1906;XLVI(18):1345–1348. doi:10.1001/jama.1906.62510450019001j
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