Quite a number of more or less important changes in the method of making some of our important standard pharmaceutical preparations have been introduced in the new eighth edition of the United States Pharmacopeia. One of the most radical of these changes is the substitution of acetic acid (10 per cent. absolute acid) in place of alcohol (95 per cent.) as the menstruum for making fluid extract of squill. During the past eight years it has been my privilege to examine personally, or to check the results obtained by an assistant, many samples representing thousands of pounds of fluid extract of squill and other heart tonics for physiologic activity. The method of assay has been substantially that given in an article published in The Journal1 for making quantitative pharmacological assays of the heart tonics.2 For the sake of clearness it may be explained that the strength of the
HOUGHTON EM. A COMPARISON OF THE PHARMACOLOGIC ACTIVITY OF THE FLUID EXTRACT OF SQUILL PREPARED ACCORDING TO THE UNITED STATES PHARMACOPEIA 1890 AND 1900. JAMA. 1906;XLVI(19):1417–1420. doi:10.1001/jama.1906.62510460011001b
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