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In some of the text-books on ophthalmology mention is made of a senile change in the fundus oculi, characterized by the appearance of small yellowish and yellowish white spots which have been regarded as hyalin or colloid degeneration in the lamina vitrea choroidea. In Noyes we find a full description under the head of degenerative changes of the choroid, in which he assumes the identity of drusen and this colloid degeneration of the lamina vitrea. He calls attention to the clinical fact that vision is not impaired in these cases. Two excellent colored plates representing two varieties of the affection are shown, to both of which I wish to call attention. In one, the large, globular, mulberry-like masses are seen both upon the nerve-head and in the outlying fundus. This plate is taken from Lawson's case, reported in the Transactions of the Ophthalmological Society of the United Kingdom, vol. III.
CARPENTER JT. EXTENSIVE COLLOID CHANGES IN THE CHOROID, WITH REPORT OF CASES. JAMA. 1895;XXV(18):737–739. doi:10.1001/jama.1895.02430440005002a
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