In examining two specimens of urine for lead in Prof. Charles S. Williamson's clinic at the College of Physicians and Surgeons, Chicago, I experienced great difficulty in using the different methods, inasmuch as some take too much time, some are not sufficiently sensitive, while others require expensive apparatus. Considering the fact that the amount of lead found in chronic poisoning rarely exceeds 10 mg. per liter, the method must be exceedingly sensitive. The methods heretofore used are that of Fresenius and Babo as described in v. Jaksch "Klinische Diagnostik," and that given by E. E. Putman in Keating's "Clycopedia of the Diseases of Children." Both of these methods require a great deal of time and considerable chemical training. Two other methods, very simple, but not sufficiently sensitive, are those of v. Jaksch1 and I. H. Abram.2
An electrolytic method was worked out by S. R. Trotman and F.
LEDERER A. A NEW METHOD FOR THE DETERMINATION OF LEAD IN THE URINE. JAMA. 1906;XLVI(21):1612–1613. doi:10.1001/jama.1906.62510480040003a
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