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Article
June 9, 1906

THE CAUSE OF THE HEART BEAT.

Author Affiliations

Professor of Physiology and Dean of the Medical Faculty, Johns Hopkins University. BALTIMORE.

JAMA. 1906;XLVI(23):1749-1753. doi:10.1001/jama.1906.62510500013003
Abstract

The Auriculoventricular Bundle.  —It was formerly held that the myogenic theory is inapplicable to the mammalian heart because no muscular connection exists between auricles and ventricles. This objection has been completely removed in recent years.On the anatomical side the work of Kent, W. His, Jr., Retzer, Braeunig, Humblet and Tawara has shown beyond doubt that a small muscular slip passes from the auricle into the ventricular septum. In man, according to Retzer, this bridge is about 1.5 mm. in thickness, 2.5 mm. in width and 18 mm. long.On the physiologic side the experiments of His, Hering, Humblet, Fredericq and especially of Erlanger, have proved with equal certainty that it is along this narrow bundle that the wave of excitation is conveyed from auricle to ventricle. The last named observer has shown in a series of brilliant experiments that if this bridge be compressed by. a specially devised clamp,

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