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June 9, 1906


JAMA. 1906;XLVI(23):1763. doi:10.1001/jama.1906.62510500027003b

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Following the experiments of Beard of Edinburgh with the use of trypsin in Jensen tumors in mice and his suggestion for the use of trypsin in carcinoma, many attempts undoubtedly are being made at present with trypsin in inoperable malignant growths. I have used trypsin in seven cases of inoperable carcinoma in different parts of the body and in one inoperable round-cell sarcoma of the thigh. I began the work ten weeks ago, and in some of the cases continued the injections for six weeks. All except one were hopeless cases from the standpoint of operation or x-rays, but in none of them was cachexia marked. I have used Fair-child's sterilized trypsin solution with the commercial name of injectio trypsi, which, I believe, was the preparation used by Beard. Beard's successful dose of one drop in mice is equivalent to 600 drops in an adult of 150 pounds weight.

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