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June 9, 1906


JAMA. 1906;XLVI(23):1768-1769. doi:10.1001/jama.1906.02510500032006

The profound anatomic changes that occur in the kidneys and liver, and to a less extent in the other parenchymatous organs, in eclampsia, leave no room for doubt that in this condition the blood of the patient is loaded with materials possessed of a high degree of toxicity. Both the origin and the nature of these poisons remain, however, among the most baffling of medical mysteries. The frequent association with marked albuminuria and the occurrence of convulsions quite similar to those of uremia led Frerichs and others to consider eclampsia as identical with uremia, and a specific disease only in that it occurs in pregnancy. That this is not the case, however, has been abundantly proved. In the first place the anatomie changes are quite different from those in uremia, in which the toxic materials seem to exert their influence chiefly on the central nervous system. In many cases of