This research was undertaken for the purpose of ascertaining whether or not the cellular substance of the typhoid bacillus shows any tendency to uniform and definite cleavage under the influence of the mineral acids, the ultimate object being to learn something of the chemical composition and structure of the molecule making up the substance of the cell. In this paper, which must be considered only a preliminary contribution, general results only are given, with the hope of being able to go more into detail subsequently.
The material used in these studies consisted of the cellular substance of a typical typhoid bacillus, which was obtained from the mesenteric glands after death from typhoid fever, and which gave in a typical manner all the characteristic cultural manifestations of this organism. The toxieity of the living culture was tested on rabbits, guinea-pigs and white rats, and then the organism was grown
WHEELER M. THE ACTION OF MINERAL ACID ON THE CELLULAR SUBSTANCE OF BACILLUS TYPHOSUS. JAMA. 1904;XLII(16):1000–1003. doi:10.1001/jama.1904.92490610005002b
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