The subject of this paper is generally recognized as presenting a distinct clinical picture, differing from all other sarcomata. The metastases may invade all the soft tissues. The distribution of the metastases appears to be by way of the blood stream and the lymphatics. There is always pigmentation, sometimes much, at other times little. In the same case we may find one nodule black and another white. The pigment is unevenly distributed. Some of the metastatic tumors appear entirely without pigment, while others in the same case are deeply pigmented. This pigment is the dark-brown, granular material known as melanin and is the same material that we find in normal skin and in pigmented moles. The disease is one of the most fatal of malignant tumors, and after metastases take place the case is practically hopeless.
The cases of multiple pigmented growths which are recorded as recovering either spontaneously or
FRICK W, HALL FJ. GENERALIZED MULTIPLE PIGMENTED SARCOMA ORIGINATING IN THE SKIN. JAMA. 1906;XLVI(25):1911–1915. doi:10.1001/jama.1906.62510520015002d
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