From its earliest use it has been known that certain errors were liable to occur in connection with the Widal test for typhoid, especially with regard to the degree of dilution of the blood to be tested and the time-limit of observation, but these possible errors have been so frequently pointed out and are so easily avoidable that the profession in general has had a great deal of confidence in the reaction. Within the last two or three years a further source of error has been pointed out, namely, the fact that certain cases of jaundice give the Widal reaction, and seemingly with dilutions as high as those generally used in the diagnosis of typhoid fever.
This aspect of the question has been reviewed by Libman1 in this country, and by Steinberg2 in Germany. Libman comes to the conclusion that jaundice per se does not cause the agglutinating
THE OCCURRENCE OF THE WIDAL REACTION IN JAUNDICE. JAMA. 1904;XLII(16):1025. doi:10.1001/jama.1904.02490610035007
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