Of the many unsolved problems in the pathogenesis of skin diseases there is one which, by reason of the broad applicability of the points involved, is of pre-eminent importance, namely, the relation of the nervous system to cutaneous inflammation. To illustrate the diversity of opinion and general confusion which obtains on this subject a few instances may be cited. There is a condition called by the French nèvrodermite; it is regarded by them as a distinct disease entity of nervous origin, but by American dermatologists the pathogenesis given is not accepted and, therefore, the condition is scarcely recognized. The adherents of the Vienna school speak of neurotische or reflectorische Entzündung or Dermatitis, thereby conceding that an inflammatory lesion may have a nervous cause. Turning to authorities in our own language, a striking example of obscurity with respect to nerve relations in pathology is to be found in the textbook of
McEWEN EL. THE RELATION OF NERVE IMPULSE TO CUTANEOUS INFLAMMATION. JAMA. 1906;XLVII(1):8–11. doi:10.1001/jama.1906.25210010008001a
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