The one certain means of controlling hemorrhage consists in the local application of mechanical measures to the bleeding point, but this is ordinarily not possible in internal hemorrhage. A few drugs applied locally appear also to possess hemostatic properties. Fortunately, the bleeding not rarely ceases spontaneously as a result of processes taking place naturally in the blood, and sometimes the cessation is attributed to the medicinal agents that may have been employed. A number of drugs have been variously proposed for the control of inaccessible hemorrhage, but it is altogether doubtful whether most of them possess any actual efficacy in this connection. The question has recently been discussed by Dr. W. E. Dixon1 on the basis of studies made in the pharmacologic laboratory at Cambridge University. As he points out, tannic acid and ferric chlorid, applied directly to a bleeding point, control hemorrhage through coagulation of proteid, while adrenalin,
THE TREATMENT OF INTERNAL HEMORRHAGE. JAMA. 1906;XLVII(1):41. doi:10.1001/jama.1906.02520010049007
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