Despite the prevalence and the frequency of eczema, and notwithstanding the vast amount of study that has been given to the subject, it must be admitted with chagrin that the etiology of this disease is as yet far from settled. As a matter of fact, differences of opinion exist, even among experts, as to the precise limitations of the disorder, and, although by the majority it is considered a clinical entity, by a few it is looked on as merely a symptomatic manifestation. In a discussion of this subject Dr. J. M. H. MacLeod1 points out that, according to prevailing views as to the nature and causation of eczema, it is variously thought to be (1) of parasitic origin, (2) due to a variety of irritants, internal or external, acting in a predisposed individual, (3) the result of nervous derangement in a predisposed person. It is almost universally
THE ETIOLOGY OF ECZEMA. JAMA. 1906;XLVII(7):513. doi:10.1001/jama.1906.02520070047009
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