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Article
May 21, 1904

HUMAN AND EXPERIMENTAL LOBAR PNEUMONIA.

JAMA. 1904;XLII(21):1358-1359. doi:10.1001/jama.1904.02490660030008
Abstract

In view of the frequence of lobar pneumonia in man it may seem remarkable that all experimenters have found it so difficult to produce the same disease in animals. A vast amount of work has been done in this direction, for the unsolved puzzle of the manner of invasion of the lung by the pneumococcus has been a strong incentive, and it is evident that if we can find a method of producing lobar pneumonia with constancy in animals, we have an important aid in learning the truth of the matter, not to mention a good starting point for studies in therapy. The usual results obtained in experiments of this kind have either been the production of a rapidly fatal septicemia without any considerable lung lesions, or else, at the best, foci of bronchopneumonic type in the lungs. A true diffuse, exudative lobar pneumonia seldom develops, no matter what the

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