In view of the frequence of lobar pneumonia in man it may seem remarkable that all experimenters have found it so difficult to produce the same disease in animals. A vast amount of work has been done in this direction, for the unsolved puzzle of the manner of invasion of the lung by the pneumococcus has been a strong incentive, and it is evident that if we can find a method of producing lobar pneumonia with constancy in animals, we have an important aid in learning the truth of the matter, not to mention a good starting point for studies in therapy. The usual results obtained in experiments of this kind have either been the production of a rapidly fatal septicemia without any considerable lung lesions, or else, at the best, foci of bronchopneumonic type in the lungs. A true diffuse, exudative lobar pneumonia seldom develops, no matter what the
HUMAN AND EXPERIMENTAL LOBAR PNEUMONIA. JAMA. 1904;XLII(21):1358–1359. doi:10.1001/jama.1904.02490660030008
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