A preliminary paper was published in The Journal, Feb. 17, 1906, describing the preparation of a serum having therapeutic value in the treatment of exophthalmic goiter. Since that date I have had a great deal more experience in the preparation of the serum, and its therapeutic effect has been carefully tried on many more patients so that it is now possible to describe improved processes for its manufacture and to state more nearly what its value is likely to be.
The theoretical basis was described in sufficient detail in the first paper. I may say, however, that since the publication of the article in the Journal of Experimental Medicine,1 describing the experiments which led to the therapeutic application in exophthalmic goiter, I have made many more experiments of the same nature, and as a result it may safely be concluded that a serum having a high degree of specificity
BEEBE SP. A SERUM HAVING THERAPEUTIC VALUE IN THE TREATMENT OF EXOPHTHALMIC GOITER. JAMA. 1906;XLVII(9):661–665. doi:10.1001/jama.1906.25210090017002c
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