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April 4, 1896


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JAMA. 1896;XXVI(14):670-671. doi:10.1001/jama.1896.02430660022003g

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Until recently typhoid fever has been regarded as a self-limiting disease, always ending in lysis and occupying a period of three or four weeks' duration. It is observed of varying degrees of intensity, from a mild attack, in which there may be only slight elevation of temperature, and the patient does not take to his bed, to the severest type, in which from the beginning there is great prostration, and the patient rapidly succumbs to the intensity of the poison.

Complications and sequelæ are to be dreaded alike in the mild and severe forms, and not infrequently in the midst of a mild attack, or after convalescence has apparently been established, we may have ulcerations of the ileum, resulting in grave hemorrhages, or perforation of intestine, with peritonitis and speedy death.

Under the old régime, there were observed four distinct periods to the disease, and a schematic representation of each

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