The fear and misgiving which attended the administration of the anti-diphtheritic serum at the outset is no longer justified. From every part of the world come numerous clinical reports attesting the value of the new treatment. Its untoward symptoms have been promptly and carefully studied, so that with proper care it is a safe and efficient remedy for the treatment of diphtheria.
In September, 1894, I treated my first case of diphtheria with anti-diphtheritic serum, a bottle of which I had obtained from Aronson's laboratory in Berlin. The case had been a severe one; the serum was used after secondary infection had developed and the case seemed hopeless. The membrane had extended where it would and could not be checked. The temperature stood at 103 degrees and pulse at 120.
The serum was injected with all due precaution. The temperature continued to rise for several hours, showing that diphtheritic intoxication
DUFFIELD G. THE USE OF ANTITOXIN IN THE TREATMENT OF DIPHTHERIA. JAMA. 1897;XXVIII(10):445–446. doi:10.1001/jama.1897.02440100013001c
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