Effusion of fluid takes place into serous cavities under a variety of conditions, principally inflammatory and cardiovascular. When present in small amount, the fluid may, and it usually does, undergo spontaneous absorption. If, however, the amount be large, not only may the fluid remain unabsorbed, but it may, beside, be a source of distinct danger by reason of the pressure it exerts on vital organs, with the resulting interference with function. To secure relief under the latter conditions, puncture or aspiration or some form of resection often becomes necessary, but even then the fluid may reaccumulate, at times with great rapidity, so that repeated operation is required. It would be a decided advantage to possess a means by which such a difficulty could be obviated, and the suggestion has recently been made on the basis of clinical experience that reaccumulation of fluid in serous cavities after aspiration can be prevented
INJECTION OF ADRENALIN TO PREVENT REACCUMULATION OF SEROUS EFFUSIONS.. JAMA. 1904;XLII(23):1496–1497. doi:10.1001/jama.1904.02490680036008
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