It is well known that various poisonous materials circulating in the blood may cause the destruction of the cells of the liver, sometimes in very small foci, sometimes much more diffusely throughout the whole organ. In many cases, as has been emphasized by Opie, this destruction may occur fairly regularly in certain portions or zones of the lobule, while in other cases it is difficult to determine any such regularity.
Necroses of similar type may be produced experimentally, as shown by Pearce and others, but they most commonly occur in the course of acute infections and intoxications. When limited in extent they may destroy so little of the liver that no definite symptoms result and the injured area is in time replaced by scar tissue, the remaining liver tissue becoming hypertrophied to compensate for that which was lost. This process may become a more or less continuous one if the
MacCALLUM WG. CIRRHOTIC CHANGES IN THE LIVER FOLLOWING A SINGLE INJURY. JAMA. 1906;XLVII(13):984–985. doi:10.1001/jama.1906.25210130008001c
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