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March 13, 1897


JAMA. 1897;XXVIII(11):483-489. doi:10.1001/jama.1897.02440110005002

A few years past no one would have listened to the assertion that a relation exists between lower organisms and certain forms of disease. The secretions were admitted to contain some elements of a physicochemic character, irritative in nature and capable of producing pathologic processes. A large class of miasmatic and contagious diseases are not only admitted by the most eminent pathologists and bacteriologists of today, but are referred by them direct to the animal and vegetable parasites. Evidence is positive proof that septicemia should be mentioned in this connection. What can be clearer since Saunderson's and Bert's investigations in 1873 of the relation between intensity of septicemia and pyemia depends upon microorganisms? I desire to present to you an original research of septicemia on guinea pigs, rabbits, mice, dogs and sparrows which were carried out in the private laboratory of DaCosta and Kyle, Philadelphia, later on continued in the